Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain

Yaniv Assaf, Peter J. Basser

Research output: Contribution to journalArticlepeer-review

Abstract

High b value diffusion-weighted images sampled at high angular resolution were analyzed using a composite hindered and restricted model of diffusion (CHARMED). Measurements and simulations of diffusion in white matter using CHARMED provide an unbiased estimate of fiber orientation with consistently smaller angular uncertainty than when calculated using a DTI model or with a dual tensor model for any given signal-to-noise level. Images based on the population fraction of the restricted compartment provide a new contrast mechanism that enhances white matter like DTI. Nevertheless, it is assumed that these images might be more sensitive than DTI to white matter disorders. We also provide here an experimental design and analysis framework to implement CHARMED MRI that is feasible on human clinical scanners.

Original languageEnglish
Pages (from-to)48-58
Number of pages11
JournalNeuroImage
Volume27
Issue number1
DOIs
StatePublished - 1 Aug 2005

Keywords

  • DTI
  • Diffusion
  • Hindered
  • MRI
  • Restricted
  • White matter
  • q space

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