Complications of acromegaly: thyroid and colon

Amit Tirosh, Ilan Shimon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Introduction: In acromegaly the long-term exposure to high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels may result in specific complications in different human organs, including the thyroid gland and the colon. Materials and Methods: We will review here the evidence available regarding the characteristic thyroid and colon complications in acromegaly. Results: This review summarizes the published data observing noncancerous structural abnormalities (thyroid nodules, colonic polyps) and thyroid and colon cancer in patients diagnosed with acromegaly. Conclusion: Thyroid micro-carcinomas are probably over-diagnosed among acromegalic patients. In regard to colon cancer, there is no sufficient data to suggest that colon cancer risk is higher in acromegaly compared to the general population.

Original languageEnglish
Pages (from-to)70-75
Number of pages6
JournalPituitary
Volume20
Issue number1
DOIs
StatePublished - 1 Feb 2017

Funding

FundersFunder number
Pfizer
Novartis

    Keywords

    • Acromegaly
    • Colon
    • Thyroid

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