Complex segregation analysis of body height, weight and BMI in pedigree data from Middle Dalmatia, Croatia

Tatjana Škarić-Jurić, Emil Ginsburg, Eugene Kobyliansky, Ida Malkin, Nina Smolej Narančić, Pavao Rudan

Research output: Contribution to journalArticlepeer-review

Abstract

It has recently been reported that the mode of inheritance of body height, weight and BMI in five ethnically and geographically different populations can be described in terms of a major gene (MG) model1. Here, using the pedigree sample from the island populations of Middle Dalmatia, Croatia (1,312 observed individuals in 462 pedigrees), the evidence is presented that supports the above findings. By applying the usual transmission probability tests, the hypothesis has been accepted that a significant part of the variation of each one of those three basic morphological traits can be attributed to the effect of a putative large-effect gene. The effect of a putative MG is responsible for 39-5% of age and sex adjusted trait's variation and for 34-48% of the total (non age-adjusted) variation of height, weight and BMI.

Original languageEnglish
Pages (from-to)135-149
Number of pages15
JournalCollegium Antropologicum
Volume27
Issue number1
StatePublished - 2003

Keywords

  • BMI
  • Body height
  • Body weight
  • Complex segregation analysis
  • Croatia

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