Complex modulation by stress of the effect of seizures on long term potentiation in mouse hippocampal slices

Nicola Maggio*, Efrat Shavit Stein, Menahem Segal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Stress has a profound effect on ability to express neuronal plasticity, learning, and memory. Likewise, epileptic seizures lead to massive changes in brain connectivity, and in ability to undergo long term changes in reactivity to afferent stimulation. In this study, we analyzed possible long lasting interactions between a stressful experience and reactivity to pilocarpine, on the ability to produce long term potentiation (LTP) in a mouse hippocampus. Pilocarpine lowers paired pulse potentiation as well as LTP in CA1 region of the mouse hippocampal slice. When stress experience precedes exposure to pilocarpine, it protects the brain from the lasting effect of pilocarpine. When stress follows pilocarpine, it exacerbates the effect of the drug, to produce a long lasting reduction in LTP. These changes are accompanied by a parallel change in blood corticosterone level. A single exposure to selective mineralo- or gluco-corticosterone (MR and GR, respectively) agonists and antagonists can mimic the stress effects, indicating that GR's underlie the lasting detrimental effects of stress whereas MRs are instrumental in counteracting the effects of stress. These studies open a new avenue of understanding of the interactive effects of stress and epileptic seizures on brain plasticity.

Original languageEnglish
Pages (from-to)860-870
Number of pages11
Issue number8
StatePublished - Aug 2017


FundersFunder number
Israel Science Foundation1091/13


    • LTP
    • hippocampus
    • status epilepticus
    • stress
    • synaptic plasticity


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