Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice

Yuval Tal, Lina Souan, Irun R. Cohen*, Zeev Meiner, Albert Taraboulos, Felix Mor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


We recently reported that immunization of mice with certain self-prion protein peptides induced specific T-cell and B-cell immune responses; importantly, this immunization was associated with a decrease in the number of protease-resistant PrPSc particles recoverable in a transplanted, scrapie-infected syngeneic tumor. The present study was carried out to determine whether immunization with the immunogenic PrP peptides might influence the natural history of experimental scrapie in mice. We immunized C57BL/6 mice with self-prion peptides in complete Freund's adjuvant (CFA) or with CFA alone as a control and then infected the mice with mouse-adapted scrapie by injection either intraperitoneally or intracerebrally. We report here that immunization with CFA, irrespective of whether prion peptides were present in the inoculum, resulted in marked prolongation of survival of the mice, whether the challenge was intracerebral or intraperitoneal. Mice in the immunized and control groups that died contained equivalent amounts of PrPSc. Thus, CFA immunization has a therapeutic effect in experimental scrapie in mice, possibly by reducing the rate of PrPSc accumulation in the brain.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalJournal of Neuroscience Research
Issue number2
StatePublished - 15 Jan 2003
Externally publishedYes


  • Freund's adjuvant
  • Immunotherapy
  • PrP
  • Scrapie
  • Transmissible spongiform encephalopathies


Dive into the research topics of 'Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice'. Together they form a unique fingerprint.

Cite this