Abstract
Sera from eight multi transfused patients, who were resistant to platelet transfusions from allogeneic donors, were tested for antiplatelet humoral antibody. Complement dependent cytotoxic humoral antibody against platelets was found in sera from six of eight patients. Cell dependent cytotoxic humoral antibody against platelets was found in sera from four of seven of these patients. Sera from two patients had cell dependent antiplatelet activity but no detectable complement dependent antiplatelet activity. Results of this study argue that both complement dependent and cell dependent humoral immunity may be important pathways for in vivo resistance to platelets.
| Original language | English |
|---|---|
| Pages (from-to) | 259-266 |
| Number of pages | 8 |
| Journal | Clinical and Experimental Immunology |
| Volume | 21 |
| Issue number | 2 |
| State | Published - 1975 |
| Externally published | Yes |