TY - JOUR
T1 - Compilation of eukaryotic sequences around transcription initiation sites
AU - Nussinov, Ruth
PY - 1986/6/21
Y1 - 1986/6/21
N2 - All vertebrate and invertebrate sequences present in the GenBank database have been aligned according to their mRNA start sites. For some cases the regions between positions -110 and +110 are presented. Previously, two general transcription initiation signals have been noted, the universal TATA box at position -30 and the CAAT box at -75. Our analysis indicates the presence of other signals, at least as significant as the CAAT. Inspection of the aligned sequences reveals the high concentration of G+C near mRNA initiation sites in non-mammalian vertebrates and in mammalians.
AB - All vertebrate and invertebrate sequences present in the GenBank database have been aligned according to their mRNA start sites. For some cases the regions between positions -110 and +110 are presented. Previously, two general transcription initiation signals have been noted, the universal TATA box at position -30 and the CAAT box at -75. Our analysis indicates the presence of other signals, at least as significant as the CAAT. Inspection of the aligned sequences reveals the high concentration of G+C near mRNA initiation sites in non-mammalian vertebrates and in mammalians.
UR - http://www.scopus.com/inward/record.url?scp=0023054599&partnerID=8YFLogxK
U2 - 10.1016/S0022-5193(86)80041-8
DO - 10.1016/S0022-5193(86)80041-8
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AN - SCOPUS:0023054599
SN - 0022-5193
VL - 120
SP - 479
EP - 487
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 4
ER -