TY - JOUR
T1 - Competitive interaction between endothelin and sarafotoxin
T2 - Binding and phosphoinositides hydrolysis in rat atria and brain
AU - Ambar, I.
AU - Kloog, Y.
AU - Schvartz, I.
AU - Hazum, E.
AU - Sokolovsky, M.
PY - 1989/1/16
Y1 - 1989/1/16
N2 - Binding studies with the structurally similar vasoconstrictor peptides 125I-endothelin and 125I-sarafotoxin b, the former of mammalian origin and the latter derived from snake venom, reveal their mutually exclusive binding to rat atrium and various regions of the rat brain. In these tissues endothelin, like sarafotoxin, induces phosphoinositide hydrolysis which is in part Ca2+-independent. It is suggested that endothelins and sarafotoxins share common binding sites and mechanisms of action.
AB - Binding studies with the structurally similar vasoconstrictor peptides 125I-endothelin and 125I-sarafotoxin b, the former of mammalian origin and the latter derived from snake venom, reveal their mutually exclusive binding to rat atrium and various regions of the rat brain. In these tissues endothelin, like sarafotoxin, induces phosphoinositide hydrolysis which is in part Ca2+-independent. It is suggested that endothelins and sarafotoxins share common binding sites and mechanisms of action.
UR - http://www.scopus.com/inward/record.url?scp=0024569727&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(89)80197-4
DO - 10.1016/S0006-291X(89)80197-4
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AN - SCOPUS:0024569727
SN - 0006-291X
VL - 158
SP - 195
EP - 201
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -