Comparison of the healing capacities of different dosages of sucralfate in the treatment of duodenal ulcer

Forty-nine patients with endoscopically proven duodenal ulcer were evaluated for six weeks in a randomized, double-blind trial comparing two regimens of sucralfate. Twenty-six patients were treated with sucralfate 4 g a day (Group 1) and another 23 with sucralfate 2 g per day (Group 2). Endoscopy was repeated after six weeks to assess ulcer healing. Ulcer healing was observed in 24 out of 26 patients in Group 1 (92.3%) and in 18 out of 23 patients in Group 2 (78.2%). There was no statistical difference between groups.