Comparison of the effects of early handling and early deprivation on conditioned stimulus, context, and spatial learning and memory in adult rats

Christopher R. Pryce, Daniela Bettschen, Nina I. Nanz-Bahr, Joram Feldon

Research output: Contribution to journalArticlepeer-review

Abstract

Effects of manipulations of the rat pup-dam relationship on affective learning and memory in adulthood have received scant systematic investigation. The authors previously described how early handling (EH; 15 min isolation/day) and early deprivation (ED; 4 hr isolation/day) exert similar effects on spontaneous adult affect (open-field behavior, acoustic startle, endocrine stress response) relative to nonhandling (NH; C. R. Pryce, D. Bettschen, N. I. Bahr, & J. Feldon, 2001). The present study demonstrates that both EH and ED adults exhibit enhanced active avoidance relative to NH adults. Fear-conditioned context and conditioned stimulus (CS) freezing were unaffected in both EH and ED, but stress hormone responses to the CS were reduced in EH males and ED females relative to NH. In the water maze, ED adults exhibited enhanced spatial learning and memory relative to NH.

Original languageEnglish
Pages (from-to)883-893
Number of pages11
JournalBehavioral Neuroscience
Volume117
Issue number5
DOIs
StatePublished - Oct 2003
Externally publishedYes

Fingerprint

Dive into the research topics of 'Comparison of the effects of early handling and early deprivation on conditioned stimulus, context, and spatial learning and memory in adult rats'. Together they form a unique fingerprint.

Cite this