Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Conformation 100%
• Hypervariable Region 100%
• KRAS 100%
• Enzyme Active Site 60%
• Dynamics 20%
• Autoinhibition 20%
• C-Terminus 20%
• Guanine 20%
• GTPase 20%
• Palmitoylation 20%
• P21 20%
• HRAS 20%

Keyphrases

• K-Ras4B 100%
• Hypervariable Region 27%
• Catalytic Domain 16%
• N-Ras 11%
• Splice Variant 11%
• Autoinhibition 5%
• NRAS mutation 5%
• KRAS mutation 5%
• GTPase 5%
• Palmitoylation 5%
• Positively Charged 5%
• Binding Region 5%
• All-atom Molecular Dynamics Simulation 5%
• Nucleotide-binding Pocket 5%
• Isoform-specific 5%
• HEC-RAS 5%
• Bound Form 5%
• Dynamic Fluctuations 5%
• Guanine nucleotide Exchange 5%
• Effector Binding 5%
• Specific Difference 5%
• RAS-driven Cancer 5%
• HRAS Gene 5%
• Signaling State 5%