TY - JOUR
T1 - Comparison of standard forward-viewing mode versus ultrawide-viewing mode of a novel colonoscopy platform
T2 - A prospective, multicenter study in the detection of simulated polyps in an in vitro colon model (with video)
AU - Gralnek, Ian M.
AU - Carr-Locke, David L.
AU - Segol, Ori
AU - Halpern, Zamir
AU - Siersema, Peter D.
AU - Sloyer, Alan
AU - Fenster, Jay
AU - Lewis, Blair S.
AU - Santo, Erwin
AU - Suissa, Alain
AU - Segev, Meytal
N1 - Funding Information:
DISCLOSURE: Drs Gralnek, Halpern, Siersema, Carr-Locke, Segol, and Suissa are consultants for Peer Medical Ltd. Dr Segev is the Medical Director of Peer Medical Ltd. This study was sponsored by Peer Medical Ltd, Caesaria, Israel.
PY - 2013/3
Y1 - 2013/3
N2 - Background: Although colonoscopy is the criterion standard for detecting colorectal adenomas and cancers, a significant percentage of adenomas are missed. Objective: To compare forward-viewing with ultrawide-viewing colonoscopy in the detection of simulated colon polyps in an in vitro colon model. Design: Prospective, multicenter. Setting: Six endoscopy units (3 in the United States and 3 in Israel). Patients: In vitro colon model with simulated colon polyps (n = 21 metallic beads). Interventions: Detection of simulated colon polyps on colonoscope withdrawal. Main Outcome Measurements: Incremental detection of simulated colon polyps and endoscopist evaluation of the usability, visibility, and maneuverability of ultrawide-viewing colonoscopy. Results: On forward-viewing colonoscopy, the number of simulated polyps (mean ± standard deviation) detected per endoscopist was 11.1 ± 2.3 polyps, a 52.9% detection rate. Simulated polyp detection rates per colon segment were 3.0 ± 0.93 (60.0%) right colon, 2.4 ± 0.87 (48.0%) transverse colon, and 5.7 ± 1.5 (51.8%) left colon. On ultrawide-viewing colonoscopy, the simulated polyp detection rate per endoscopist significantly increased to 18.0 ± 1.98 polyps, an overall 85.7% polyp detection rate (P <.001). Simulated polyp detection rates were also significantly higher by using the ultrawide-viewing mode in each colon segment, 4.5 ± 0.65 polyps (90.0%) right colon, 4.0 ± 0.87 (80.0%) polyps transverse colon, and 9.6 ± 1.28 polyps (87.3%) left colon (all comparisons, P <.001). Importantly, the ultrawide-viewing mode detected significantly more "hidden" simulated polyps (81.9% vs 31.9%, P <.0001). Limitations: Nonrandomized design, use of a colon model, and "simulated" colon polyps. Conclusions: Ultrawide-view colonoscopy significantly improved simulated polyp detection in a colon model. Clinical studies in human subjects should be pursued to further evaluate this new endoscopic technology.
AB - Background: Although colonoscopy is the criterion standard for detecting colorectal adenomas and cancers, a significant percentage of adenomas are missed. Objective: To compare forward-viewing with ultrawide-viewing colonoscopy in the detection of simulated colon polyps in an in vitro colon model. Design: Prospective, multicenter. Setting: Six endoscopy units (3 in the United States and 3 in Israel). Patients: In vitro colon model with simulated colon polyps (n = 21 metallic beads). Interventions: Detection of simulated colon polyps on colonoscope withdrawal. Main Outcome Measurements: Incremental detection of simulated colon polyps and endoscopist evaluation of the usability, visibility, and maneuverability of ultrawide-viewing colonoscopy. Results: On forward-viewing colonoscopy, the number of simulated polyps (mean ± standard deviation) detected per endoscopist was 11.1 ± 2.3 polyps, a 52.9% detection rate. Simulated polyp detection rates per colon segment were 3.0 ± 0.93 (60.0%) right colon, 2.4 ± 0.87 (48.0%) transverse colon, and 5.7 ± 1.5 (51.8%) left colon. On ultrawide-viewing colonoscopy, the simulated polyp detection rate per endoscopist significantly increased to 18.0 ± 1.98 polyps, an overall 85.7% polyp detection rate (P <.001). Simulated polyp detection rates were also significantly higher by using the ultrawide-viewing mode in each colon segment, 4.5 ± 0.65 polyps (90.0%) right colon, 4.0 ± 0.87 (80.0%) polyps transverse colon, and 9.6 ± 1.28 polyps (87.3%) left colon (all comparisons, P <.001). Importantly, the ultrawide-viewing mode detected significantly more "hidden" simulated polyps (81.9% vs 31.9%, P <.0001). Limitations: Nonrandomized design, use of a colon model, and "simulated" colon polyps. Conclusions: Ultrawide-view colonoscopy significantly improved simulated polyp detection in a colon model. Clinical studies in human subjects should be pursued to further evaluate this new endoscopic technology.
UR - http://www.scopus.com/inward/record.url?scp=84873633269&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2012.12.011
DO - 10.1016/j.gie.2012.12.011
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C2 - 23410700
AN - SCOPUS:84873633269
SN - 0016-5107
VL - 77
SP - 472
EP - 479
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
IS - 3
ER -
