Comparison of pregnancy outcome of euploid fetuses with increased nuchal translucency (NT) expressed in NT MoM or delta-NT

R. Maymon, S. Tercanli, E. Dreazen, G. Sartorius, W. Holzgreve, A. Herman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the outcome of euploid fetuses with increased nuchal translucency thickness (NT) expressed in multiples of the median (MoM) or delta-NT. Methods: Included in the study were euploid fetuses with increased NT ≥ 95th centile, for which information about pregnancy outcome was available. The following parameters were defined as an adverse outcome: miscarriage, structural anomalies justifying termination of pregnancy, and structural anomalies, genetic syndromes and neurodevelopmental problems diagnosed postnatally. Fetal outcome according to NT MoM and delta-NT was calculated using different cut-off values. Calculations of the odds ratio for adverse outcome were performed using either NT MoM or delta-NT as a predictor in logistic regression models. Results: The study comprised 168 euploid fetuses. Of these, 38 (23%) had an adverse outcome: 11 (6%) had miscarriages, 14 (8%) were terminated because of fetal abnormalities detected on the prenatal scan and 13 (7%) were found postnatally to have abnormalities. The incidence of cases exhibiting an adverse outcome was 5.3%, 19.2% and 58.5% for NT values of 1.6-1.9, 2.0-3.0 and > 3.0 MoM, respectively (P < 0.0001, χ2 test), and 3.9%, 16.7% and 62.8% for delta-NT values of 1.0-1.4, 1.5-2.5 and > 2.5 mm, respectively (P < 0.0001, χ2 test). Using cut-offs of 2.0 MoM and delta-NT of 1.5 mm, the odds ratios for adverse outcome were 10.2 (95% CI, 3.4-30.4) and 15.4 (95% CI, 4.2-43.6), respectively. Conclusion: Both the NT MoM and delta-NT approaches may be used to determine cases which require additional antenatal investigation as well as fetal karyotyping. For this purpose we suggest using a cut-off of either 2.0 MoM or a delta-NT of 1.5 mm.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalUltrasound in Obstetrics and Gynecology
Volume23
Issue number5
DOIs
StatePublished - May 2004

Keywords

  • Delta-NT
  • Euploid fetuses
  • Fetal abnormalities
  • Increased nuchal translucency
  • Multiple of the median
  • Pregnancy outcome

Fingerprint

Dive into the research topics of 'Comparison of pregnancy outcome of euploid fetuses with increased nuchal translucency (NT) expressed in NT MoM or delta-NT'. Together they form a unique fingerprint.

Cite this