TY - JOUR
T1 - Comparison of ganglion cell loss and cone loss in experimental glaucoma
AU - Wygnanski, T.
AU - Desatnik, H.
AU - Quigley, H. A.
AU - Glovinsky, Y.
N1 - Funding Information:
Accepted for publication Feb. 14, 1995. From the Goldschleger Eye Institute, Sadder School of Medicine, Tel-Aviv University, Tel Aviv, Israel (Drs. Wygnanski, Desatnik, and Glovinsky), and the Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland (Dr. Quigley). This study was supported in part by a grant from the Krieger Foundation, Baltimore, Maryland, by Public Health Service research grants EY 02120 (Dr. Quigley) and EY 01765 (Wilmer Ophthalmological Institute) awarded by the National Eye Institute, Bethesda, Maryland, and by National Glaucoma Research, a program of the American Health Assistance Foundation, Rockville, Maryland. Reprint requests to Tamara Wygnanski, M.D., Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel; fax: 972-3-635-0317.
PY - 1995
Y1 - 1995
N2 - PURPOSE: To compare the loss of ganglion cells to cone loss in the macular area of monkey eyes with experimental glaucoma. METHODS: Experimental glaucoma was induced in eyes of three cynomolgus monkeys by argon laser applications to the trabecular meshwork. The average duration ± S.D. of glaucoma in the experimental animals was 3.8 ± 0.5 months. Glaucomatous damage was estimated, before the animals were killed, by evaluating stereoscopic photographs of the optic disk and red-free photographs of the nerve fiber layer. Ganglion cell nucleoli and cone pedicles were counted by using light microscopy from slides containing strips of retinal tissue. Cell density was then calculated by using the modified Abercrombie formula. Percent loss of ganglion cells and cones was determined from three eyes of three monkeys in 300-μm segments that were 900 to 1,200 μm superior and inferior to the foveal center. RESULTS: Colic loss was not found at 4.5 to 6 degrees eccentricity above and below the fovea, whether damage was mild or severe. The average loss ± S.D. of ganglion cells was 81.1% ± 10.7%, whereas the average cone loss was only 3.5% ± 6.4%. CONCLUSIONS: Marked parafoveal cone loss was not found in experimental glaucoma in which extensive damage to ganglion cells occurred.
AB - PURPOSE: To compare the loss of ganglion cells to cone loss in the macular area of monkey eyes with experimental glaucoma. METHODS: Experimental glaucoma was induced in eyes of three cynomolgus monkeys by argon laser applications to the trabecular meshwork. The average duration ± S.D. of glaucoma in the experimental animals was 3.8 ± 0.5 months. Glaucomatous damage was estimated, before the animals were killed, by evaluating stereoscopic photographs of the optic disk and red-free photographs of the nerve fiber layer. Ganglion cell nucleoli and cone pedicles were counted by using light microscopy from slides containing strips of retinal tissue. Cell density was then calculated by using the modified Abercrombie formula. Percent loss of ganglion cells and cones was determined from three eyes of three monkeys in 300-μm segments that were 900 to 1,200 μm superior and inferior to the foveal center. RESULTS: Colic loss was not found at 4.5 to 6 degrees eccentricity above and below the fovea, whether damage was mild or severe. The average loss ± S.D. of ganglion cells was 81.1% ± 10.7%, whereas the average cone loss was only 3.5% ± 6.4%. CONCLUSIONS: Marked parafoveal cone loss was not found in experimental glaucoma in which extensive damage to ganglion cells occurred.
UR - http://www.scopus.com/inward/record.url?scp=0029129202&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(14)72606-6
DO - 10.1016/S0002-9394(14)72606-6
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AN - SCOPUS:0029129202
SN - 0002-9394
VL - 120
SP - 184
EP - 189
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 2
ER -