Comparison of clinical outcomes of influenza A and B at the 2017–2018 influenza season: a cohort study

T. Avni, T. Babich, A. Nir, D. Yahav, H. Shaked, N. Sorek, H. Ben Zvi, J. Bishara, A. Atamna*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Influenza has significant morbidity and mortality. Some experts consider infection with influenza B as milder than that with influenza A. The objective of this study is to evaluate the outcomes of hospitalized patients with laboratory-confirmed influenza A or B in 2017–2018 influenza season. All hospitalized patients between October 2017 and April 2018 with laboratory-confirmed influenza A and B were included. The primary composite outcomes were pneumonia/myocarditis/encephalitis, mechanical ventilation, ICU admission, and 30-day mortality. Secondary outcomes were 30-/90-day mortality, length of hospital stay, and readmission rates. The study included 201 influenza A and 325 influenza B. For the primary composite outcome, no significant difference was demonstrated between influenza A and B. Rates of mortality were similar at 30 and 90 days. Influenza A had higher pneumonia rates and mechanical ventilation. On multivariate analysis, higher Charlson’s score, hypoalbuminemia, and vasopressor use were associated with 30-day mortality, while infection with either influenza A or B was not. Influenza A was associated with higher pneumonia and mechanical ventilation rates. However, influenza B resulted with similar 30-day mortality rate as influenza A.

Original languageEnglish
Pages (from-to)1109-1114
Number of pages6
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume39
Issue number6
DOIs
StatePublished - 1 Jun 2020

Keywords

  • HN
  • Influenza
  • Mortality
  • Pneumonia

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