Comparison between bronchial response to inhaled hypoosmolar and isoosmolar solutions of sodium cromoglycate after exercise challenge

R. Soferman; S. Kivity; B. Marcus; M. Topilsky

Comparison between bronchial response to inhaled hypoosmolar and isoosmolar solutions of sodium cromoglycate after exercise challenge

R. Soferman^*
, S. Kivity
, B. Marcus
, M. Topilsky

^*Corresponding author for this work

Clinical Departments

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effectiveness of a sodium cromoglycate isoosmolar solution (288 mOsmol/L) versus hypoosmolar commercial solution (40 mOsmol/L) was studied in 14 asthmatic children with exercise-induced asthma. The mean FEV₁ after exercise in patients pretreated with a sodium cromoglycate hypotonic solution compared with FEV₁ at rest was -2% ± 10%. The mean FEV₁ after exercise in patients pretreated with an isotonic solution compared with FEV₁ at rest was 3% ± 6%. This statistically significant difference (P<.01) proves that the effectiveness of sodium cromoglycate can be improved by raising the osmolarity to isotonic levels.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Annals of Allergy
Volume	64
Issue number	2 I
State	Published - 1990

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Cite this

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title = "Comparison between bronchial response to inhaled hypoosmolar and isoosmolar solutions of sodium cromoglycate after exercise challenge",

abstract = "The effectiveness of a sodium cromoglycate isoosmolar solution (288 mOsmol/L) versus hypoosmolar commercial solution (40 mOsmol/L) was studied in 14 asthmatic children with exercise-induced asthma. The mean FEV1 after exercise in patients pretreated with a sodium cromoglycate hypotonic solution compared with FEV1 at rest was -2\% ± 10\%. The mean FEV1 after exercise in patients pretreated with an isotonic solution compared with FEV1 at rest was 3\% ± 6\%. This statistically significant difference (P<.01) proves that the effectiveness of sodium cromoglycate can be improved by raising the osmolarity to isotonic levels.",

author = "R. Soferman and S. Kivity and B. Marcus and M. Topilsky",

year = "1990",

language = "אנגלית",

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T1 - Comparison between bronchial response to inhaled hypoosmolar and isoosmolar solutions of sodium cromoglycate after exercise challenge

AU - Soferman, R.

AU - Kivity, S.

AU - Marcus, B.

AU - Topilsky, M.

PY - 1990

Y1 - 1990

N2 - The effectiveness of a sodium cromoglycate isoosmolar solution (288 mOsmol/L) versus hypoosmolar commercial solution (40 mOsmol/L) was studied in 14 asthmatic children with exercise-induced asthma. The mean FEV1 after exercise in patients pretreated with a sodium cromoglycate hypotonic solution compared with FEV1 at rest was -2% ± 10%. The mean FEV1 after exercise in patients pretreated with an isotonic solution compared with FEV1 at rest was 3% ± 6%. This statistically significant difference (P<.01) proves that the effectiveness of sodium cromoglycate can be improved by raising the osmolarity to isotonic levels.

AB - The effectiveness of a sodium cromoglycate isoosmolar solution (288 mOsmol/L) versus hypoosmolar commercial solution (40 mOsmol/L) was studied in 14 asthmatic children with exercise-induced asthma. The mean FEV1 after exercise in patients pretreated with a sodium cromoglycate hypotonic solution compared with FEV1 at rest was -2% ± 10%. The mean FEV1 after exercise in patients pretreated with an isotonic solution compared with FEV1 at rest was 3% ± 6%. This statistically significant difference (P<.01) proves that the effectiveness of sodium cromoglycate can be improved by raising the osmolarity to isotonic levels.

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AN - SCOPUS:0025174146

SN - 0003-4738

VL - 64

SP - 143

EP - 146

JO - Annals of Allergy

JF - Annals of Allergy

IS - 2 I

ER -

Comparison between bronchial response to inhaled hypoosmolar and isoosmolar solutions of sodium cromoglycate after exercise challenge

Abstract

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