Comparison between bronchial response to inhaled hypoosmolar and isoosmolar solutions of sodium cromoglycate after exercise challenge

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Abstract

The effectiveness of a sodium cromoglycate isoosmolar solution (288 mOsmol/L) versus hypoosmolar commercial solution (40 mOsmol/L) was studied in 14 asthmatic children with exercise-induced asthma. The mean FEV1 after exercise in patients pretreated with a sodium cromoglycate hypotonic solution compared with FEV1 at rest was -2% ± 10%. The mean FEV1 after exercise in patients pretreated with an isotonic solution compared with FEV1 at rest was 3% ± 6%. This statistically significant difference (P<.01) proves that the effectiveness of sodium cromoglycate can be improved by raising the osmolarity to isotonic levels.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalAnnals of Allergy
Volume64
Issue number2 I
StatePublished - 1990

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