Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

Eyal Heller; Tomas Garcia-Sanchez; Yonatan Moshkovits; Raul Rabinovici; Dvora Grynberg; Amit Segev; Samuel J. Asirvatham; Antoni Ivorra; Elad Maor

doi:10.1016/j.jacep.2021.05.003

Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

Eyal Heller, Tomas Garcia-Sanchez, Yonatan Moshkovits, Raul Rabinovici, Dvora Grynberg, Amit Segev, Samuel J. Asirvatham, Antoni Ivorra, Elad Maor^*

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.

Original language	English
Pages (from-to)	959-964
Number of pages	6
Journal	JACC: Clinical Electrophysiology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1016/j.jacep.2021.05.003
State	Published - Aug 2021

Funding

Funders	Funder number
Ministry of Business and Knowledge of the Government of Catalonia	2017 BP 00032
State Research Agency of the Spanish government
Mayo Clinic	PID2019-110120RBI00/AEI/10.13039/501100011033
Ministerio de Ciencia, Innovación y Universidades
Institució Catalana de Recerca i Estudis Avançats
Tel Aviv University
Nicholas and Elizabeth Slezak Super Center for Cardiac Research and Biomedical Engineering

Keywords

H-FIRE
electroporation
muscle contraction
pulsed field ablation

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10.1016/j.jacep.2021.05.003

Cite this

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title = "Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model",

abstract = "This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.",

keywords = "H-FIRE, electroporation, muscle contraction, pulsed field ablation",

author = "Eyal Heller and Tomas Garcia-Sanchez and Yonatan Moshkovits and Raul Rabinovici and Dvora Grynberg and Amit Segev and Asirvatham, {Samuel J.} and Antoni Ivorra and Elad Maor",

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doi = "10.1016/j.jacep.2021.05.003",

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AU - Heller, Eyal

AU - Garcia-Sanchez, Tomas

AU - Moshkovits, Yonatan

AU - Rabinovici, Raul

AU - Grynberg, Dvora

AU - Segev, Amit

AU - Asirvatham, Samuel J.

AU - Ivorra, Antoni

AU - Maor, Elad

PY - 2021/8

Y1 - 2021/8

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KW - H-FIRE

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Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

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