Comparative Study of Parenteral Penicillin G vs. Amoxicillin-Clavulanate for the Treatment of Dentoalveolar Abscess in Hospitalized Children

Amos Adler, Irit Gadot de-Vries, Jacob Amir, Liat Ashkenazi-Hoffnung

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To compare the clinical efficacy and the safety profiles of parenteral penicillin G vs. amoxicillin-clavulanate for the treatment of dentoalveolar abscess (DA) in hospitalized pediatric patients. Methods: A retrospective cohort study that was conducted at the Schneider Children's Medical Center in Israel. Results: Seventy-one patients that were included, 25 received parenteral penicillin G and 46 amoxicillin-clavulanate. There were no significant differences in the baseline clinical features except for higher rate of females in the amoxicillin-clavulanate group. Patients that were treated with penicillin G had shorter duration of fever, swelling and total length-of-stay (4.16 vs. 5 days in the penicillin G vs. amoxicillin-clavulanate groups, respectively, p = 0.007) and lower need for surgical intervention. Side effect were minor in both groups. In multivariate analysis, antimicrobial regimen was the only significant factor related with the total length-of-stay (p < 0.001). Conclusions: In pediatric patients hospitalized for DA, parenteral penicillin G was associated with better outcome compared with amoxicillin-clavulanate.

Original languageEnglish
Article number700188
JournalFrontiers in Pediatrics
Volume9
DOIs
StatePublished - 27 Aug 2021

Keywords

  • antimicrobial
  • dentoalveolar abscess
  • hospitalized
  • parenteral therapy
  • surgical extraction

Fingerprint

Dive into the research topics of 'Comparative Study of Parenteral Penicillin G vs. Amoxicillin-Clavulanate for the Treatment of Dentoalveolar Abscess in Hospitalized Children'. Together they form a unique fingerprint.

Cite this