Comparative "omics" of the fusarium fujikuroi species complex highlights differences in genetic potential and metabolite synthesis

Eva Maria Niehaus, Martin Münsterkötter, Robert H. Proctor, Daren W. Brown, Amir Sharon, Yifat Idan, Liat Oren-Young, Christian M. Sieber, Ondřej Novák, Aleš Pěnčík, Danuše Tarkowská, Kristýna Hromadová, Stanley Freeman, Marcel Maymon, Meirav Elazar, Sahar A. Youssef, El Said M. El-Shabrawy, Abdel Baset A. Shalaby, Petra Houterman, Nelson L. BrockImmo Burkhardt, Elena A. Tsavkelova, Jeroen S. Dickschat, Petr Galuszka, Ulrich Güldener, Bettina Tudzynski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Species of the Fusarium fujikuroi species complex (FFC) cause a wide spectrum of often devastating diseases on diverse agricultural crops, including coffee, fig, mango, maize, rice, and sugarcane. Although species within the FFC are difficult to distinguish by morphology, and their genes often share 90% sequence similarity, they can differ in host plant specificity and life style. FFC species can also produce structurally diverse secondary metabolites (SMs), including the mycotoxins fumonisins, fusarins, fusaric acid, and beauvericin, and the phytohormones gibberellins, auxins, and cytokinins. The spectrum of SMs produced can differ among closely related species, suggesting that SMs might be determinants of host specificity. To date, genomes of only a limited number of FFC species have been sequenced. Here, we provide draft genome sequences of three more members of the FFC: a single isolate of F. mangiferae, the cause of mango malformation, and two isolates of F. proliferatum, one a pathogen of maize and the other an orchidendophyte. Wecomparedthesegenomes to publicly availablegenomesequences of threeother FFCspecies. Thecomparisons revealed species-specific and isolate-specific differences in the composition and expression (in vitro and in planta) of genes involved in SMproduction including those for phytohormomebiosynthesis. Such differences have the potential to impact host specificity and, as in the case of F. proliferatum, the pathogenic versus endophytic life style.

Original languageEnglish
Pages (from-to)3574-3599
Number of pages26
JournalGenome Biology and Evolution
Volume8
Issue number11
DOIs
StatePublished - Nov 2016

Keywords

  • Evolution
  • Fusarium fujikuroi species complex
  • Genome sequencing
  • In planta expression
  • Metabolomics
  • Secondary metabolism

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