TY - JOUR
T1 - Comparative immunohistochemical study of endometrioid and serous papillary carcinoma of endometrium
AU - Halperin, R.
AU - Zehavi, S.
AU - Habler, L.
AU - Hadas, E.
AU - Bukovsky, I.
AU - Schneider, D.
PY - 2001
Y1 - 2001
N2 - Objective: The aim of this study was to determine whether immunohistochemical analysis of molecular parameters can provide an alternative method for classification of endometrial cancer cases according to their aggressiveness. Methods: Sixty-four cases of endometrial carcinoma were assigned to three groups: group I - 28 cases of endometrioid well and moderately differentiated (G1-G2) carcinoma; group II - 14 cases of endometrioid poorly differentiated (G3) carcinoma; group III - 22 cases of serous papillary endometrial cancer. Immunohistochemistry was used to determine the existence of estrogen receptors (ER), progesterone receptors (PR), and the expression of bcl-2, p53, HER-2/neu and Ki-67. Results: There was a significant difference in the immunohistochemical profile of the studied molecular parameters comparing the three study groups. The endometrioid G1-G2 cases (group I) were characterized by increased immunoreactivity for ER and PR (85.7% and 78.6%, respectively), increased immunoreactivity for bcl-2 (42.8%) and low expression of p53 (14.3%) and HER-2/neu (14.3%). In contrast to group I cases, the serous papillary endometrial cancer cases (group III) were characterized by immunonegativity for ER, PR and bcl-2 and high immunoreactivity for p53 (81.8%) and HER-2/neu (45.4%). The endometrioid G3 cases (group II) demonstrated an intermediate immunoprofile, characterized by immunonegativity for ER, PR and HER-2/neu, low immunoreactivity for bcl-2 (7.1%) and high expression of p53 (57.1%). The expression of Ki-67 did not differ significantly comparing the different cases of endometrial cancer. Conclusion: This study provides evidence that the immunohistochemical analysis of endometrial carcinoma differentiates between different grades and histological types, thus being useful in the distinction of high risk cases.
AB - Objective: The aim of this study was to determine whether immunohistochemical analysis of molecular parameters can provide an alternative method for classification of endometrial cancer cases according to their aggressiveness. Methods: Sixty-four cases of endometrial carcinoma were assigned to three groups: group I - 28 cases of endometrioid well and moderately differentiated (G1-G2) carcinoma; group II - 14 cases of endometrioid poorly differentiated (G3) carcinoma; group III - 22 cases of serous papillary endometrial cancer. Immunohistochemistry was used to determine the existence of estrogen receptors (ER), progesterone receptors (PR), and the expression of bcl-2, p53, HER-2/neu and Ki-67. Results: There was a significant difference in the immunohistochemical profile of the studied molecular parameters comparing the three study groups. The endometrioid G1-G2 cases (group I) were characterized by increased immunoreactivity for ER and PR (85.7% and 78.6%, respectively), increased immunoreactivity for bcl-2 (42.8%) and low expression of p53 (14.3%) and HER-2/neu (14.3%). In contrast to group I cases, the serous papillary endometrial cancer cases (group III) were characterized by immunonegativity for ER, PR and bcl-2 and high immunoreactivity for p53 (81.8%) and HER-2/neu (45.4%). The endometrioid G3 cases (group II) demonstrated an intermediate immunoprofile, characterized by immunonegativity for ER, PR and HER-2/neu, low immunoreactivity for bcl-2 (7.1%) and high expression of p53 (57.1%). The expression of Ki-67 did not differ significantly comparing the different cases of endometrial cancer. Conclusion: This study provides evidence that the immunohistochemical analysis of endometrial carcinoma differentiates between different grades and histological types, thus being useful in the distinction of high risk cases.
KW - Endometrioid carcinoma of endometrium
KW - Grade
KW - Immunohistochemistry
KW - Molecular markers
KW - Serous papillary carcinoma of endometrium
UR - http://www.scopus.com/inward/record.url?scp=0034793145&partnerID=8YFLogxK
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AN - SCOPUS:0034793145
SN - 0392-2936
VL - 22
SP - 122
EP - 126
JO - European Journal of Gynaecological Oncology
JF - European Journal of Gynaecological Oncology
IS - 2
ER -