Comparative genomic hybridization in polycythemia vera and essential thrombocytosis patients

Yair Herishanu, Michael Lishner, Yonit Bomstein, Yona Kitay-Cohen, Moshe D. Fejgin, Elena Gaber, Aliza Amiel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Polycythemia vera (PV) and essential thrombocytosis (ET) are clonal chronic myeloproliferative disorders originating from a multipotent stem cell. Bone marrow examinations reveal chromosomal abnormalities in 15-43% of PV patients and 5% of ET patients, but no specific recurring abnormality has been found to date. We aimed to find cytogenetic aberrations in PV and ET by comparative genomic hybridization (CGH), a relatively new molecular cytogenetic technique. In this study, CGH analysis was performed on peripheral blood leukocytes of 12 PV patients and 8 ET patients. One patient (8.3%) with PV had an abnormal karyotype with a deletion in 7q11.2 and one patient with ET (12.5%) had a gain in 18p. Peripheral blood analysis by CGH revealed a low frequency of cytogenetic abnormalities in PV and ET patients. However, using CGH we were able to detect two cytogenetic aberrations that were not reported previously in these disorders.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume128
Issue number2
DOIs
StatePublished - 15 Jul 2001

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