Comparative analysis of homocysteine concentrations in patients with retinal vein occlusion versus thrombotic and atherosclerotic disorders

Anat Kesler, Varda Shalev, Ori Rogowski, Orit Shimron, Bracha Shainberg, Ben Ami Sela, Itzhak Shapira, Ophira Salomon, Shlomo Berliner

Research output: Contribution to journalArticlepeer-review

Abstract

The objectives of the present study were to determine the concentrations of plasma homocysteine in a large (n = 562) cohort of patients with retinal vein occlusion (RVO) and to compare them with the values observed in other vascular thrombotic and atherosclerotic conditions. Results were compared with those observed in patients with deep vein thrombosis (n = 1700), pulmonary embolism (n = 542), transient ischemic attack (n = 1301), cerebrovascular accident (n = 1299), myocardial infarction (n = 3087), as well as peripheral artery occlusive disease (n = 1946). No differences were found between the age-adjusted estimated marginal mean ± SE for homocysteine concentrations in individuals with RVO and in those who had other atherosclerotic and atherothrombotic diseases The respective concentrations for RVO, deep vein thrombosis, pulmonary embolism, transient ischemic attack, cerebrovascular accident, myocardial infarction, and peripheral artery occlusive disease were 13.8 ± 0.4, 14.7 ± 0.3, 14.3 ± 0.5, 14.2 ± 0.3,14.6 ± 0.3, 13.8 ± 0.2, 14.4 ± 0.2 pmol/l for men and 11.4 ± 0.4, 10.7 ± 0.2, 10.8 ± 0.3, 10.8 ± 0.2, 11.8 ± 0.2, 11.2 ± 0.2 pmol/l for women. In conclusion, the concentrations of homocysteine observed in patients with RVO are similar to those detected in other thrombotic and atherosclerotic vascular disorders. In view of the fact that this is a common disorder of the elderly, increased homocysteine concentrations often reported in patients with RVO could reflect the underlying atherothrombotic condition and might not necessarily be specifically related to the RVO per se. This information is relevant in researching the potential etiopathologic role, if any, of increased homocysteine concentrations in RVO.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalBlood Coagulation and Fibrinolysis
Volume19
Issue number4
DOIs
StatePublished - Jun 2008

Keywords

  • Homocysteine
  • Retinal vein occlusion
  • Thrombotic disorders

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