TY - JOUR
T1 - Comparative analysis of cell parameter groups for breast cancer detection
AU - Blokh, David
AU - Stambler, Ilia
AU - Afrimzon, Elena
AU - Platkov, Max
AU - Shafran, Yana
AU - Korech, Eden
AU - Sandbank, Judith
AU - Zurgil, Naomi
AU - Deutsch, Mordechai
N1 - Funding Information:
This research was supported by The Komen Foundation, The Horowitz Foundation and by US Army Medical Research and Material Command Grant DAMD17-01-1-0131.
PY - 2009/6
Y1 - 2009/6
N2 - We present a method for the comparative analysis of parameter groups according to their correlation to disease. The theoretical basis of the proposed method is Information Theory and Nonparametric Statistics. Normalized mutual information is used as the measure of correlation between parameters, and statistical conclusions are based on ranking. The fluorescence polarization (FP) parameter is considered as the principal diagnostic characteristic. The FP was measured in fluorescein diacetate (FDA)-stained individual peripheral blood mononuclear cells (PBMC), derived from healthy subjects and breast cancer (BC) patients, under different stimulation conditions: by tumor tissue, the mitogen phytohemagglutinin (PHA) or without the stimulants. The FP parameters were grouped according to their correlation with breast cancer. It was established that the greatest difference between cells of BC patients and healthy subjects is found in the PHA test (parameter P1).
AB - We present a method for the comparative analysis of parameter groups according to their correlation to disease. The theoretical basis of the proposed method is Information Theory and Nonparametric Statistics. Normalized mutual information is used as the measure of correlation between parameters, and statistical conclusions are based on ranking. The fluorescence polarization (FP) parameter is considered as the principal diagnostic characteristic. The FP was measured in fluorescein diacetate (FDA)-stained individual peripheral blood mononuclear cells (PBMC), derived from healthy subjects and breast cancer (BC) patients, under different stimulation conditions: by tumor tissue, the mitogen phytohemagglutinin (PHA) or without the stimulants. The FP parameters were grouped according to their correlation with breast cancer. It was established that the greatest difference between cells of BC patients and healthy subjects is found in the PHA test (parameter P1).
KW - Breast cancer (BC)
KW - Fluorescence polarization (FP)
KW - Information Theory
KW - Mitogenic stimulation
KW - Nonparametric Statistics
KW - Peripheral blood mononuclear cells (PBMC)
KW - Selecting parameter groups
UR - http://www.scopus.com/inward/record.url?scp=63649153923&partnerID=8YFLogxK
U2 - 10.1016/j.cmpb.2009.01.005
DO - 10.1016/j.cmpb.2009.01.005
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AN - SCOPUS:63649153923
SN - 0169-2607
VL - 94
SP - 239
EP - 249
JO - Computer Methods and Programs in Biomedicine
JF - Computer Methods and Programs in Biomedicine
IS - 3
ER -
