Comparative analysis of Bayer wide-range C-reactive protein (wr-CRP) and the Dade-Behring high sensitivity C-reactive protein (hs-CRP) in patients with inflammatory bowel disease

Nitsan Maharshak, Yaron Arbel, Amir Gal-Oz, Ori Rogowski, Itzhak Shapira, Shlomo Berliner, Yaffa Vered, Jonathan Canaani, Iris Dotan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective:The recently introduced Bayer wide-range C-reactive protein (wr-CRP) assay might be relevant for the real-time low-cost and online determination of inflammatory bowel disease (IBD) activity. Our aim was to examine whether wr-CRP can substitute for the Dade Behring high sensitivity C-reactive protein (hs-CRP) assay in IBD patients. Methods: A total of 71 patients with IBD, of whom 48.had Crohn's disease CD and 23 had ulcerative colitis (UC) with various intensities of disease activity participated in the study. The CRP of patients who were under treatment at the Department of Gastroenterology and Liver Diseases were measured using both wr-CRP and the hs-CRP. Results: A significant (r = 0.995; P < 0.001) correlation was noted between the hs-CRP and wr-CRP measurements for the whole sample as well as for the two diseases, CD (r = 0.994; P < 0.001) and UC (r = 0.997; P < 0.001), which were analyzed separately. Conclusion: The Bayer wr-CRP assay might be a useful low-cost and real-time inflammation-sensitive biomarker in patients with IBD.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalJournal of Digestive Diseases
Volume9
Issue number3
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Biomarker
  • C-reactive protein
  • Inflammatory bowel disease

Fingerprint

Dive into the research topics of 'Comparative analysis of Bayer wide-range C-reactive protein (wr-CRP) and the Dade-Behring high sensitivity C-reactive protein (hs-CRP) in patients with inflammatory bowel disease'. Together they form a unique fingerprint.

Cite this