TY - JOUR
T1 - Comparative analysis between dextran sulfate adsorption and direct adsorption of lipoproteins in their capability to reduce erythrocyte adhesiveness/aggregation in the peripheral blood
AU - Schechner, V.
AU - Berliner, Shlomo
AU - Shapira, I.
AU - Justo, D.
AU - Hershcovici, T.
AU - Zeltser, D.
AU - Beigel, Y.
PY - 2004/2
Y1 - 2004/2
N2 - The purpose of this study was to compare the degree of erythrocyte adhesiveness/aggregation (EAA) reduction of two low-density lipoprotein (LDL) apheretic procedures, namely direct adsorption of lipoproteins (DALI) and dextran sulfate adsorption (DSA). A significant (P < 0.001) reduction of EAA was noted in six hypercholesterolemic patients who underwent a total of 40 apheretic sessions and no difference was noted in the degree of EAA reduction by the two techniques. Thus, being a real-time and point-of-care test, the erythrocyte adhesiveness/aggregation test can be applied in relevant situations of acute ischemia, where therapeutic LDL apheresis could improve the hemorheology of individuals with increased concentrations of cholesterol and inflammatory sensitive proteins.
AB - The purpose of this study was to compare the degree of erythrocyte adhesiveness/aggregation (EAA) reduction of two low-density lipoprotein (LDL) apheretic procedures, namely direct adsorption of lipoproteins (DALI) and dextran sulfate adsorption (DSA). A significant (P < 0.001) reduction of EAA was noted in six hypercholesterolemic patients who underwent a total of 40 apheretic sessions and no difference was noted in the degree of EAA reduction by the two techniques. Thus, being a real-time and point-of-care test, the erythrocyte adhesiveness/aggregation test can be applied in relevant situations of acute ischemia, where therapeutic LDL apheresis could improve the hemorheology of individuals with increased concentrations of cholesterol and inflammatory sensitive proteins.
KW - Erythrocyte adhesiveness/aggregation test
KW - Low-density lipoprotein apheresis
UR - http://www.scopus.com/inward/record.url?scp=3042825427&partnerID=8YFLogxK
U2 - 10.1111/j.1526-0968.2004.00105.x
DO - 10.1111/j.1526-0968.2004.00105.x
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C2 - 15128018
AN - SCOPUS:3042825427
SN - 1091-6660
VL - 8
SP - 39
EP - 44
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
IS - 1
ER -