Comparative analysis between dextran sulfate adsorption and direct adsorption of lipoproteins in their capability to reduce erythrocyte adhesiveness/aggregation in the peripheral blood

V. Schechner, Shlomo Berliner, I. Shapira, D. Justo, T. Hershcovici, D. Zeltser, Y. Beigel

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to compare the degree of erythrocyte adhesiveness/aggregation (EAA) reduction of two low-density lipoprotein (LDL) apheretic procedures, namely direct adsorption of lipoproteins (DALI) and dextran sulfate adsorption (DSA). A significant (P < 0.001) reduction of EAA was noted in six hypercholesterolemic patients who underwent a total of 40 apheretic sessions and no difference was noted in the degree of EAA reduction by the two techniques. Thus, being a real-time and point-of-care test, the erythrocyte adhesiveness/aggregation test can be applied in relevant situations of acute ischemia, where therapeutic LDL apheresis could improve the hemorheology of individuals with increased concentrations of cholesterol and inflammatory sensitive proteins.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume8
Issue number1
DOIs
StatePublished - Feb 2004

Keywords

  • Erythrocyte adhesiveness/aggregation test
  • Low-density lipoprotein apheresis

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