Common perinatal insults diminish cord blood RANTES

Benjamin Dekel, Marina Rubinstein, Ram Mazkeret, Danny Lotan, Gideon Paret*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrate that the cord blood RANTES concentrations are reduced in full-term newborns who were born from meconium-stained amniotic fluid as compared with full-term newborns born after normal delivery. Since RANTES inhibits immunodeficiency virus (HIV) entry into macrophages, thereby bestowing increased resistance to HIV (including protection in utero), we propose that common perinatal events might precipitate higher perinatal transmission of HIV.

Original languageEnglish
Pages (from-to)70-72
Number of pages3
JournalBiology of the Neonate
Volume82
Issue number1
DOIs
StatePublished - 2002

Keywords

  • Chemokines
  • HIV
  • Neonate
  • RANTES

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