Common origin of transmissible venereal tumors (TVT) in dogs

N. Katzir, E. Arman, D. Cohen, D. Givol, G. Rechavi

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We determined the sequence of the 1.5-kb insert upstream to c-myc in the transmissible venereal tumor (TVT) of dogs. The sequence is highly homologous to the 3' region of the mammalian repetitive LINE element. The insert is bound by a 10-bp repeat indicating DNA transposition by a mechanism involving reverse transcriptase. We analysed DNA of four TVT tumors from various geographical locations as well as normal canine DNA for the presence of the LINE insert. The results indicate that in all TVT tumurs, but not in normal tissues, the same LINE insert was present upstream to c-myc. This result suggests that TVT tumors in various dogs may have a common cellular origin.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalOncogene
Volume1
Issue number4
StatePublished - 1987
Externally publishedYes

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