Common bile duct pressure in dogs after opiate injection - epidural versus intravenous route

Elik Vatashsky, Yuval Haskel, Benzion Beilin, H. B. Aronson

Research output: Contribution to journalArticlepeer-review

Abstract

The effect on the common bile duct pressure of epidurally injected morphine and fentanyl, was compared with that of intravenous injections of the same drugs in 12 mongrel dogs. Intravenous injection of morphine (0.1 mg.kg-1) or fentanyl (0.01 mg.kg-1) significantly elevated the common bite duct pressure from 10.48 ± 0.37 to 21.68 ± 0.33 cm H2O and from 9.66 ± 0.33 to 14.14 ± 0.21 cm H2O respectively. These increases occurred within 4-15 minutes after injection and lasted for about 2-3 hours. When the narcotics in identical dosages were injected epidurally, the common bile duct pressures were unchanged during the four hours of investigation. Further studies are planned to determine whether this beneficial effect of epidural narcotics applies also in the human clinical situation.

Original languageEnglish
Pages (from-to)650-653
Number of pages4
JournalCanadian Journal of Anaesthesia
Volume31
Issue number6
DOIs
StatePublished - Nov 1984
Externally publishedYes

Keywords

  • analgesia postoperative: epidural
  • analgesics: morphine, fentanyl
  • common bile duct
  • pressure

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