Common bile duct pressure in dogs after opiate injection - epidural versus intravenous route

Elik Vatashsky; Yuval Haskel; Benzion Beilin; H. B. Aronson

doi:10.1007/BF03008762

Common bile duct pressure in dogs after opiate injection - epidural versus intravenous route

Elik Vatashsky^*, Yuval Haskel, Benzion Beilin, H. B. Aronson

^*Corresponding author for this work

Hadassah University Medical Centre

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect on the common bile duct pressure of epidurally injected morphine and fentanyl, was compared with that of intravenous injections of the same drugs in 12 mongrel dogs. Intravenous injection of morphine (0.1 mg.kg^-1) or fentanyl (0.01 mg.kg^-1) significantly elevated the common bite duct pressure from 10.48 ± 0.37 to 21.68 ± 0.33 cm H₂O and from 9.66 ± 0.33 to 14.14 ± 0.21 cm H₂O respectively. These increases occurred within 4-15 minutes after injection and lasted for about 2-3 hours. When the narcotics in identical dosages were injected epidurally, the common bile duct pressures were unchanged during the four hours of investigation. Further studies are planned to determine whether this beneficial effect of epidural narcotics applies also in the human clinical situation.

Original language	English
Pages (from-to)	650-653
Number of pages	4
Journal	Canadian Journal of Anaesthesia
Volume	31
Issue number	6
DOIs	https://doi.org/10.1007/BF03008762
State	Published - Nov 1984
Externally published	Yes

Keywords

analgesia postoperative: epidural
analgesics: morphine, fentanyl
common bile duct
pressure

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10.1007/BF03008762

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title = "Common bile duct pressure in dogs after opiate injection - epidural versus intravenous route",

abstract = "The effect on the common bile duct pressure of epidurally injected morphine and fentanyl, was compared with that of intravenous injections of the same drugs in 12 mongrel dogs. Intravenous injection of morphine (0.1 mg.kg-1) or fentanyl (0.01 mg.kg-1) significantly elevated the common bite duct pressure from 10.48 ± 0.37 to 21.68 ± 0.33 cm H2O and from 9.66 ± 0.33 to 14.14 ± 0.21 cm H2O respectively. These increases occurred within 4-15 minutes after injection and lasted for about 2-3 hours. When the narcotics in identical dosages were injected epidurally, the common bile duct pressures were unchanged during the four hours of investigation. Further studies are planned to determine whether this beneficial effect of epidural narcotics applies also in the human clinical situation.",

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AU - Vatashsky, Elik

AU - Haskel, Yuval

AU - Beilin, Benzion

AU - Aronson, H. B.

PY - 1984/11

Y1 - 1984/11

N2 - The effect on the common bile duct pressure of epidurally injected morphine and fentanyl, was compared with that of intravenous injections of the same drugs in 12 mongrel dogs. Intravenous injection of morphine (0.1 mg.kg-1) or fentanyl (0.01 mg.kg-1) significantly elevated the common bite duct pressure from 10.48 ± 0.37 to 21.68 ± 0.33 cm H2O and from 9.66 ± 0.33 to 14.14 ± 0.21 cm H2O respectively. These increases occurred within 4-15 minutes after injection and lasted for about 2-3 hours. When the narcotics in identical dosages were injected epidurally, the common bile duct pressures were unchanged during the four hours of investigation. Further studies are planned to determine whether this beneficial effect of epidural narcotics applies also in the human clinical situation.

AB - The effect on the common bile duct pressure of epidurally injected morphine and fentanyl, was compared with that of intravenous injections of the same drugs in 12 mongrel dogs. Intravenous injection of morphine (0.1 mg.kg-1) or fentanyl (0.01 mg.kg-1) significantly elevated the common bite duct pressure from 10.48 ± 0.37 to 21.68 ± 0.33 cm H2O and from 9.66 ± 0.33 to 14.14 ± 0.21 cm H2O respectively. These increases occurred within 4-15 minutes after injection and lasted for about 2-3 hours. When the narcotics in identical dosages were injected epidurally, the common bile duct pressures were unchanged during the four hours of investigation. Further studies are planned to determine whether this beneficial effect of epidural narcotics applies also in the human clinical situation.

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KW - analgesics: morphine, fentanyl

KW - common bile duct

KW - pressure

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Common bile duct pressure in dogs after opiate injection - epidural versus intravenous route

Abstract

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