Combined therapy of granulocyte transfusions, intravenous opsonins and antibiotics for gram-negative pneumonia in neutropenic cancer patients

A. Nagler, E. Naparstek, D. Engelhard

Research output: Contribution to journalArticlepeer-review

Abstract

Four patients with hematological malignancies, following bone marrow transplantation, who developed documented gram-negative [Klebsiella pneumoniae (2), Pseudomonas aeruginosa or Acinetobacter calcoaceticus] pneumonia during absolute neutropenia, were treated with a combination of antimicrobial therapy, granulocyte transfusions, and high-dose intravenous immunoglobulin. The patients recovered following this regimen, including 2 who had septic shock and respiratory failure, necessitating intubation and mechanical ventilation. These data suggest that therapy combining antimicrobial agents, granulocyte transfusions and opsonins may be effective in neutropenic patients who develop gram-negative pneumonia.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalActa Haematologica
Volume91
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • Granulocyte transfusion
  • Infection
  • Intravenous immune globulin
  • Neutropenia
  • Opsonins
  • Pneumonia

Fingerprint

Dive into the research topics of 'Combined therapy of granulocyte transfusions, intravenous opsonins and antibiotics for gram-negative pneumonia in neutropenic cancer patients'. Together they form a unique fingerprint.

Cite this