Combined linkage and association sib-pair analysis for quantitative traits

D. W. Fulker, S. S. Cherny*, P. C. Sham, J. K. Hewitt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalAmerican Journal of Human Genetics
Volume64
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

Funding

FundersFunder number
National Institutes of HealthMH-53668, MH-53480, AA-07330, EY-12562, DA-11015, MH-43899, AA-10556
Medical Research Council

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