Combined Factor V and Factor VIII Deficiency among Non-Ashkenazi Jews

Combined factor V and factor VIII deficiency is a well-documented hereditary bleeding disorder that has so far been reported in 21 families.^1,2 The study of this disorder is of great interest, since the normal function of factor V and factor VIII is controlled by separate genes — a fact that can be inferred from the existence of hemophilia A and von Willebrand's disease (factor VIII deficiencies), on the one hand, and of parahemophilia (a factor V deficiency), on the other. Recently, a mechanism for the combined factor V and factor VIII deficiency has been proposed by Marlar and Griffin,³ who. . .