Combined Factor V and Factor VIII Deficiency

Joseph Sweeney, Barry Wenz, U. Seligsohn

Research output: Contribution to journalLetterpeer-review


To the Editor: Seligsohn et al. (Nov. 4 issue)* described the autosomal inheritance of combined factor V and factor VIII deficiency. It would be a mistake, however, to assume that all cases are attributable to this mechanism. The fortuitous inheritance of factor V deficiency with either von Willebrand's disease or hemophilia A is characterized by reduced levels of these factors. Although the frequency of the involved genes makes such fortuitous combinations improbable, consanguinity greatly alters the probability. We would like to describe such a case. The patient, a 30-year-old man, was the only offspring of a father and daughter. He.

Original languageEnglish
Pages (from-to)656-657
Number of pages2
JournalNew England Journal of Medicine
Issue number11
StatePublished - 17 Mar 1983


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