Combined electroconvulsive-clozapine therapy

Marina Kupchik, Baruch Spivak*, Roberto Mester, Ilya Reznik, Noah Gonen, Abraham Weizman, Moshe Kotler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


We reviewed 36 reported psychiatric patients who were treated with a combination of electroconvulsive therapy (ECT) and clozapine. The indication of the ECT-clozapine treatment was resistance to classical antipsychotic agents, clozapine, or ECT alone. Sixty-seven percent of the patients benefited from the combined treatment. In most of the patients, the combined treatment was safe and well tolerated. Adverse reactions occurred in 16.6% of the patients and included prolonged ECT-induced seizures (one case), supraventricular (one case) and sinus tachycardia, and blood pressure elevation. It seems that combined ECT-clozapine treatment is effective and safe. This strategy may be a therapeutic option in treatment-resistant patients.

Original languageEnglish
Pages (from-to)14-16
Number of pages3
JournalClinical Neuropharmacology
Issue number1
StatePublished - Jan 2000


  • Clozapine
  • Electroconvulsive therapy
  • Schizophrenia


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