TY - JOUR
T1 - Combined electroconvulsive-clozapine therapy
AU - Kupchik, Marina
AU - Spivak, Baruch
AU - Mester, Roberto
AU - Reznik, Ilya
AU - Gonen, Noah
AU - Weizman, Abraham
AU - Kotler, Moshe
PY - 2000/1
Y1 - 2000/1
N2 - We reviewed 36 reported psychiatric patients who were treated with a combination of electroconvulsive therapy (ECT) and clozapine. The indication of the ECT-clozapine treatment was resistance to classical antipsychotic agents, clozapine, or ECT alone. Sixty-seven percent of the patients benefited from the combined treatment. In most of the patients, the combined treatment was safe and well tolerated. Adverse reactions occurred in 16.6% of the patients and included prolonged ECT-induced seizures (one case), supraventricular (one case) and sinus tachycardia, and blood pressure elevation. It seems that combined ECT-clozapine treatment is effective and safe. This strategy may be a therapeutic option in treatment-resistant patients.
AB - We reviewed 36 reported psychiatric patients who were treated with a combination of electroconvulsive therapy (ECT) and clozapine. The indication of the ECT-clozapine treatment was resistance to classical antipsychotic agents, clozapine, or ECT alone. Sixty-seven percent of the patients benefited from the combined treatment. In most of the patients, the combined treatment was safe and well tolerated. Adverse reactions occurred in 16.6% of the patients and included prolonged ECT-induced seizures (one case), supraventricular (one case) and sinus tachycardia, and blood pressure elevation. It seems that combined ECT-clozapine treatment is effective and safe. This strategy may be a therapeutic option in treatment-resistant patients.
KW - Clozapine
KW - Electroconvulsive therapy
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0033960302&partnerID=8YFLogxK
U2 - 10.1097/00002826-200001000-00003
DO - 10.1097/00002826-200001000-00003
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AN - SCOPUS:0033960302
SN - 0362-5664
VL - 23
SP - 14
EP - 16
JO - Clinical Neuropharmacology
JF - Clinical Neuropharmacology
IS - 1
ER -