Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder

M. Moldavsky*, D. Stein, R. Benatov, P. Sirota, A. Elizur, Y. Matzner, A. Weizman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Three adolescent and two adult patients suffering from chronic excited psychoses (either schizophrenia or schizoaffective disorder) resistant to traditional neuroleptics and clozapine were treated with combined clozapine- lithium. Improvement was assessed with the Positive and Negative Symptoms Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impressions, administered before and during combined clozapine-lithium treatment. All patients demonstrated a significant improvement with this combination. There was no occurrence of agranulocytosis, neuroleptic malignant syndrome or other clinically significant adverse effects.

Original languageEnglish
Pages (from-to)104-106
Number of pages3
JournalEuropean Psychiatry
Issue number2
StatePublished - 1998


  • Clozapine
  • Lithium
  • Schizoaffective disorder
  • Schizophrenia


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