TY - JOUR
T1 - Combined autoimmune disease in a patient with AIDS
AU - Zandman-Goddard, G.
AU - Peeva, E.
AU - Barland, P.
PY - 2002
Y1 - 2002
N2 - Immune dysregulation in HIV-infected patients, along with the new medications for treatment of AIDS that possess immunomodulating potential, may lead to an increased incidence of autoimmune diseases in this patient population. However, the presence of combined autoimmune diseases in an AIDS patient is rare. Relapsing polychondritis (RP) is an uncommon inflammatory disease manifested by recurrent attacks of auricular chondritis. The presence of type II and IX collagen antibodies, and their association with HLA-DR4 and other autoimmune diseases, suggests that antiself reactions may be present. Sarcoidosis is a granulomatous disease manifested by inflammation of the lungs, eyes and joints. In the peripheral blood there is depressed cellular immunity and enhanced humoral immunity. We here describe a case of coexisting RP and sarcoidosis in an AIDS patient.
AB - Immune dysregulation in HIV-infected patients, along with the new medications for treatment of AIDS that possess immunomodulating potential, may lead to an increased incidence of autoimmune diseases in this patient population. However, the presence of combined autoimmune diseases in an AIDS patient is rare. Relapsing polychondritis (RP) is an uncommon inflammatory disease manifested by recurrent attacks of auricular chondritis. The presence of type II and IX collagen antibodies, and their association with HLA-DR4 and other autoimmune diseases, suggests that antiself reactions may be present. Sarcoidosis is a granulomatous disease manifested by inflammation of the lungs, eyes and joints. In the peripheral blood there is depressed cellular immunity and enhanced humoral immunity. We here describe a case of coexisting RP and sarcoidosis in an AIDS patient.
KW - AIDS
KW - Autoimmune disease
KW - HIV
KW - Relapsing polychondritis
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=0036204305&partnerID=8YFLogxK
U2 - 10.1007/s100670200017
DO - 10.1007/s100670200017
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C2 - 11954891
AN - SCOPUS:0036204305
SN - 0770-3198
VL - 21
SP - 70
EP - 72
JO - Clinical Rheumatology
JF - Clinical Rheumatology
IS - 1
ER -