Combined 5‐fluorouracil (5‐FU) and radiation therapy following resection of locally advanced gastric carcinoma

E. Gez, A. Sulkes, T. Yablonsky‐Peretz, Z. Weshler

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty‐five patients with locally advanced but resectable adenocarcinoma of the stomach were given concomitant postoperative radiotherapy to the tumor bed and chemotherapy with 5‐Fluorouracil (5‐FU). Twenty‐two of the patients had regional lymph node involvement and seven had residual tumor in the surgical margins. Radiotherapy was delivered to a total dose of 5,000 rads in 7 weeks with a two‐week split. 5‐FU was given daily the first 3 days of each treatment period and was then continued weekly for a minimum of 1 year. At a median follow‐up time of 19 months, 11 patients have relapsed, two locally and nine distally, and all have died. Thirteen patients remain alive, all but one disease‐free, for a median of 21 months from diagnosis. One additional patient died of unrelated causes, free of tumor. The actuarial median survival for the whole group stands at 33 months with a projected 5‐year survival of 40%. Treatment has been well tolerated.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalJournal of Surgical Oncology
Volume31
Issue number2
DOIs
StatePublished - Feb 1986
Externally publishedYes

Keywords

  • adjuvant chemotherapy
  • locally advanced gastric cancer
  • radiotherapy

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