Colorectal carcinoma in childhood: A retrospective multicenter study

Dragan Kravarusic, Elad Feigin, Elena Dlugy, Ran Steinberg, Arthur Baazov, Ilan Erez, Ludvig Lazar, Vadim Kapuller, Moshe Grunspan, Shifra Ash, Enrique Freud

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: Colorectal carcinoma, a common adult malignancy, has an estimated childhood incidence of 0.3 to 1.5/million in Western countries and 0.2/million in Israel. Diagnosis is difficult because adult screening measures are unfeasible in children. The tumor is frequently associated with predisposing genetic factors, aggressive biological behavior, and poor prognosis. The aim of this multicenter study was to document the clinical profile, treatment and prognosis of colorectal carcinoma in children in Israel. PATIENTS AND METHODS: The clinical, laboratory, therapeutic, and prognostic parameters of all 7 children from 4 medical centers in Israel who were diagnosed with colorectal carcinoma over a 25-y period were reviewed. RESULTS: Patients presented with rectal bleeding (4 of 7), abdominal pain (2 of 7), and abdominal distension (2 of 7). Average time to diagnosis was 6 months. Six patients underwent surgery (1 refused), and 5 received chemotherapy. Histopathological studies showed poorly differentiated mucinous adenocarcinoma, signet-ring type, in 4 cases, moderately differentiated adenocarcinoma in 2, and well-differentiated carcinoma in 1. Three patients died of the disease, 2 shortly after diagnosis. One patient with recurrent metastatic disease was lost to follow-up. CONCLUSION: Colorectal carcinoma in children is characterized by aggressive tumor behavior and delayed diagnosis, resulting in a worse prognosis than in adults. Heightened physician awareness of the possibility of this disease in children, with special attention to adolescents with predisposing factors and rectal bleeding, could help to improve outcome.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume44
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Carcinoma
  • Childhood
  • Colorectal
  • Rectal bleeding

Fingerprint

Dive into the research topics of 'Colorectal carcinoma in childhood: A retrospective multicenter study'. Together they form a unique fingerprint.

Cite this