Colonic proliferation and colon cancer risk

H. Kashtan, H. S. Stern*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The purpose of this review is to discuss some of the recent hypotheses regarding the dietary etiology of colorectal cancer. We will review some of the epidemiological background and animal studies that were performed to test these hypotheses. The use of the rectal mucosal proliferation rate as measured by thymidine labelling index as an intermediate endpoint for clinical studies is discussed, including the results of testing these hypotheses using this marker. We believe that all hypotheses must eventually be tested in the human model and that carefully controlled, sequential analyses of each acceptable hypothesis is the most prudent road to understanding the environmental causes of colorectal cancer.

Original languageEnglish
Pages (from-to)904-910
Number of pages7
JournalIsrael Journal of Medical Sciences
Issue number12
StatePublished - 1992
Externally publishedYes


  • Colorectal cancer
  • Diet
  • Mucosal proliferation rate
  • Thymidine labelling index


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