Colchicine prophylaxis for frequent periodic fever, aphthous stomatitis, pharyngitis and adenitis episodes

Diana Tasher, Michal Stein, Ilan Dalal, Eli Somekh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To review our experience with colchicine for the prophylaxis of PFAPA (periodic fever, aphthous stomatitis, pharyngitis, adenitis). Patients and Methods: Prophylaxis with colchicine was offered to patients with frequent PFAPA episodes defined as episodes occurring every ≤14 days. Nine patients, aged 3.5-11.0 years, were treated with colchicine at a daily dosage of 0.5-1.0 mg and were followed up for 6-48 months (mean 2 years). Results: Colchicine treatment increased the interval between the episodes in eight out of the nine patients. The interval between the episodes was significantly increased following colchicine treatment from an average of 1.7 weeks to 8.4 weeks (p < 0.006). Only one patient had an abdominal pain that responded to dose adjustment.

Original languageEnglish
Pages (from-to)1090-1092
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics
Volume97
Issue number8
DOIs
StatePublished - Aug 2008

Keywords

  • Colchicine
  • PFAPA
  • Prophylaxis

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