Colchicine was found to inhibit the first phase of casein induced synthesis of murine amyloid. When mice were treated with colchicine during the first 7 days of an amyloid induction regimen or when colchicine was given to the donor mice in a transfer model, the amyloidogenic stimulus of casein was blocked completely. Amyloid synthesis was, however, not interrupted by the administration of colchicine during the last 7 days of the casein regimen nor by colchicine treatment of recipient mice in a transfer model. The mechanism of colchicine action is unknown. Its interference with sol gel transformation and its effect on lysosomal activity, together with the association of lysosomes with amyloid synthesis seems an indication that the drug prevents the extracellular assembly of amyloid subunits into fibrils. However, the failure of colchicine to prevent amyloid synthesis in the recipient animals renders this assumption rather unlikely.
|Number of pages||3|
|Journal||British Journal of Experimental Pathology|
|State||Published - 1976|