Intestinal permeability was determined in rats receiving colchicine 0.5 ± 0.15 mg day‐1 in drinking water (30 mg L‐1) for periods up to 23 days. The lactulose/mannitol method was used to determine whole gut permeability before and on days 2, 4, 8, 18 and 23 of colchicine administration. The 8‐h urinary lactulose excretion following the test meal increased significantly in rats receiving colchicine, compared with the pretreatment value. Increased lactulose permeability was present after 2 days and remained stable throughout the experimental period. Mannitol urinary excretion was not changed. Colchicine increases intestinal tight junction permeability by an as yet undetermined mechanism.
|Number of pages||6|
|Journal||Acta Physiologica Scandinavica|
|State||Published - Mar 1995|
- intestinal permeability