TY - JOUR
T1 - Coincidence imaging using 2 dual-head γ-camera systems, with and without attenuation correction
AU - Even-Sapir, Einat
AU - Yuzefovich, Bella
AU - Miller, Elka
AU - Bouhnik, Jean Paul
AU - Zak, Osnat
AU - Lerman, Hedva
AU - Lievshitz, Genady
AU - Levin, Charles
PY - 2004/12
Y1 - 2004/12
N2 - Objective: Coincidence imaging enhances the potential for imaging a greater number of patients with 18F-FDG in centers that do not have dedicated PET systems. The purpose of this study was to compare, in a clinical setting, coincidence imaging for tumor detection using 2 dual-head γ-camera systems, one equipped with a 5/8-in. (16 mm) detector (CoDe5) and the other equipped with a newly designed 1-in. (25.4 mm) detector (CoDe8) with an x-ray tube installed in its gantry. Methods: Thirty consecutive patients were studied by both systems during the same visit and had 4 image sets for comparison: CoDe5 without attenuation correction (CoDe5NC), CoDe8 with (CoDe8AC) and without (CoDe8NC) attenuation correction, and fused coincidence-CT images. The target-to-background ratio (T/Bg ratio) and target-to-nontarget ratio (T/NT ratio) were calculated for each tumor site. Results: On visual assessment, 61 tumor sites were detected on CoDe8AC images. Of these, 59 (97%) were detected on CoDe8NC and 54 (88%) were detected on CoDe5NC images. Fused images improved image interpretation in 10 patients (33%) compared with coincidence images alone. Data added by fusion were of clinical relevance in 6 patients (20%). On quantitative assessment, the number of accepted events by the CoDe8 was significantly higher than that by CoDe5 (5.21 ± 1.46 million vs. 1.27 ± 0.36 million, P < 0.001). When comparing CoDe5 with CoDe8 images without attenuation correction, the T/Bg and T/NT ratios were significantly higher on the CoDe8 images (P < 0.0005 and P < 0.0005, respectively). When comparing CoDe8 images with and without attenuation correction, the T/Bg ratio was better on the attenuation-corrected images (P < 0.0005). Conclusion: Coincidence imaging with 1-in. detectors and attenuation correction improve image quality and, to a lesser extent, the tumor detection rate compared with the 5/8-in. detectors and noncorrected images. The data added by fusion of coincidence images to CT findings were clinically relevant in 20% of the patients.
AB - Objective: Coincidence imaging enhances the potential for imaging a greater number of patients with 18F-FDG in centers that do not have dedicated PET systems. The purpose of this study was to compare, in a clinical setting, coincidence imaging for tumor detection using 2 dual-head γ-camera systems, one equipped with a 5/8-in. (16 mm) detector (CoDe5) and the other equipped with a newly designed 1-in. (25.4 mm) detector (CoDe8) with an x-ray tube installed in its gantry. Methods: Thirty consecutive patients were studied by both systems during the same visit and had 4 image sets for comparison: CoDe5 without attenuation correction (CoDe5NC), CoDe8 with (CoDe8AC) and without (CoDe8NC) attenuation correction, and fused coincidence-CT images. The target-to-background ratio (T/Bg ratio) and target-to-nontarget ratio (T/NT ratio) were calculated for each tumor site. Results: On visual assessment, 61 tumor sites were detected on CoDe8AC images. Of these, 59 (97%) were detected on CoDe8NC and 54 (88%) were detected on CoDe5NC images. Fused images improved image interpretation in 10 patients (33%) compared with coincidence images alone. Data added by fusion were of clinical relevance in 6 patients (20%). On quantitative assessment, the number of accepted events by the CoDe8 was significantly higher than that by CoDe5 (5.21 ± 1.46 million vs. 1.27 ± 0.36 million, P < 0.001). When comparing CoDe5 with CoDe8 images without attenuation correction, the T/Bg and T/NT ratios were significantly higher on the CoDe8 images (P < 0.0005 and P < 0.0005, respectively). When comparing CoDe8 images with and without attenuation correction, the T/Bg ratio was better on the attenuation-corrected images (P < 0.0005). Conclusion: Coincidence imaging with 1-in. detectors and attenuation correction improve image quality and, to a lesser extent, the tumor detection rate compared with the 5/8-in. detectors and noncorrected images. The data added by fusion of coincidence images to CT findings were clinically relevant in 20% of the patients.
KW - Coincidence imaging
KW - F-FDG
KW - Neoplasms
KW - PET
KW - γ-camera
UR - http://www.scopus.com/inward/record.url?scp=28744433078&partnerID=8YFLogxK
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C2 - 15576340
AN - SCOPUS:28744433078
SN - 0091-4916
VL - 32
SP - 190
EP - 197
JO - Journal of Nuclear Medicine Technology
JF - Journal of Nuclear Medicine Technology
IS - 4
ER -
