Cognitive impairment in antiphospholipid syndrome: Evidence from animal models

Simone Appenzeller, Aline Tamires Lapa, Caio Rodrigues Guirau, Jozélio Freire De Carvalho, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review


Although antiphospholipid syndrome (APS) is a multisystem prothrombotic condition, its inflammatory nature has been increasingly recognized in recent years. Stroke and transitory ischemic attacks are the neurological manifestations included in APS criteria, however many other neurological involvements have been attributed to antiphospholipid antibodies (aPL), such as seizures, transverse myelitis, and cognitive impairment. In this article we will review evidence from animal model that explain the role of aPL in cognition.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalClinical Rheumatology
Issue number3
StatePublished - Mar 2012
Externally publishedYes


  • Animal models
  • Antiphospholipid syndrome
  • Cognitive impairment


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