Cognitive function and the risk for diabetes among young men

Gilad Twig*, Israel Gluzman, Amir Tirosh, Hertzel C. Gerstein, Gal Yaniv, Arnon Afek, Estela Derazne, Dorit Tzur, Avraham Karasik, Barak Gordon, Eyal Fruchter, Gadi Lubin, Assaf Rudich, Tali Cukierman-Yaffe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


OBJECTIVE: Diabetes is a risk factor for an accelerated rate of cognitive decline and dementia. However, the relationship between cognitive function and the subsequent development of diabetes is unclear. RESEARCH DESIGN AND METHODS: We conducted a historical-prospective cohort study merging data collected at premilitary recruitment assessment with information collected at the Staff Periodic Examination Center of the Israeli Army Medical Corps. Included were men aged 25 years or older without a history of diabetes at the beginning of follow-up with available data regarding their general intelligence score (GIS), a comprehensive measure of cognitive function, at age 17 years. RESULTS: Among 35,500 men followed for a median of 5.5 years, 770 new cases of diabetes were diagnosed. After adjustment for age, participants in the lowest GIS category had a 2.6-fold greater risk for developing diabetes compared with those in the highest GIS category. In multivariable analysis adjusted for age, BMI, fasting plasma glucose, sociogenetic variables, and lifestyle risk factors, those in the lowest GIS category had a twofold greater risk for incident diabetes when compared with the highest GIS category (hazard ratio 2.1 [95% CI 1.5 -3.1]; P < 0.001). Additionally, participants in the lowest GIS category developed diabetes at a mean age of 39.5 ± 4.7 years and those in the highest GIS group at amean age of 41.5 ± 5.1 years (P for comparison 0.042). CONCLUSIONS: This study demonstrates that in addition to a potential causal link between diabetes and enhanced cognitive decline, lower cognitive function at late adolescence is independently associated with an elevated risk for future diabetes.

Original languageEnglish
Pages (from-to)2982-2988
Number of pages7
JournalDiabetes Care
Issue number11
StatePublished - 1 Nov 2014


Dive into the research topics of 'Cognitive function and the risk for diabetes among young men'. Together they form a unique fingerprint.

Cite this