Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder

Robert L. Trestman, Richard S.E. Keefe, Vivian Mitropoulou, Philip D. Harvey, Marie L. deVegvar, Sonia Lees-Roitman, Michael Davidson, Andrew Aronson, Jeremy Silverman, Larry J. Siever

Research output: Contribution to journalArticlepeer-review


There is evidence that some schizophrenic patients have deficits on tests of cognitive function, particularly tests of executive function, including the Wisconsin Card Sorting Test (WCST) and the Trail-making Test, Part B. This study was conducted to determine the generalizability of these findings across the schizophrenia spectrum to schizotypal personality disorder (SPD). Forty DSM-III SPD patients, 56 nonschizophrenia-related other personality disorder (OPD) patients, and 32 normal volunteers from two medical centers performed tests of executive function such as the WCST, Trail-making Part B, Stroop Word-Color Test, and Verbal Fluency, as well as tests of more general intellectual functioning such as the Wechsler Intelligence Scale-Revised Vocabulary and Block Design subtests, and Trail-making Part A. SPD patients performed more poorly on the WCST and on Trail-making Part B than did OPD patients or normal subjects; the groups did not differ on tests of general intellectual functioning. SPD patients may share some of the cognitive deficits observed in schizophrenia.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalPsychiatry Research
Issue number1-2
StatePublished - 29 Nov 1995
Externally publishedYes


  • Neuropsychology
  • Personality disorder
  • Schizophrenia spectrum
  • Trail-making Test Part B
  • Wisconsin Card Sorting Test


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