Cognitive enhancement of healthy older adults using hyperbaric oxygen: A randomized controlled trial

Hadanny Amir; Daniel Kotovsky Malka; Suzin Gil; Boussi Gross Rahav; Catalogna Merav; Dagan Kobi; Hachmo Yafit; Abu Hamed Ramzia; Sasson Efrat; Fishlev Gregory; Lang Erez; Polak Nir; Doenyas Keren; Friedman Mony; Tal Sigal; Zemel Yonatan; Bechor Yair; Efrati Shai

doi:10.18632/aging.103571

Cognitive enhancement of healthy older adults using hyperbaric oxygen: A randomized controlled trial

Hadanny Amir^*, Daniel Kotovsky Malka, Suzin Gil, Boussi Gross Rahav, Catalogna Merav, Dagan Kobi, Hachmo Yafit, Abu Hamed Ramzia, Sasson Efrat, Fishlev Gregory, Lang Erez, Polak Nir, Doenyas Keren, Friedman Mony, Tal Sigal, Zemel Yonatan, Bechor Yair, Efrati Shai^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.

Original language	English
Pages (from-to)	13740-13761
Number of pages	22
Journal	Aging
Volume	12
Issue number	13
DOIs	https://doi.org/10.18632/aging.103571
State	Published - 2020

Keywords

Aging
Cerebral blood flow
Cognitive
Hyperbaric oxygen
Perfusion

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10.18632/aging.103571

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Amir, H., Malka, D. K., Gil, S., Rahav, B. G., Merav, C., Kobi, D., Yafit, H., Ramzia, A. H., Efrat, S., Gregory, F., Erez, L., Nir, P., Keren, D., Mony, F., Sigal, T., Yonatan, Z., Yair, B., & Shai, E. (2020). Cognitive enhancement of healthy older adults using hyperbaric oxygen: A randomized controlled trial. Aging, 12(13), 13740-13761. https://doi.org/10.18632/aging.103571

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title = "Cognitive enhancement of healthy older adults using hyperbaric oxygen: A randomized controlled trial",

abstract = "More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.",

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author = "Hadanny Amir and Malka, {Daniel Kotovsky} and Suzin Gil and Rahav, {Boussi Gross} and Catalogna Merav and Dagan Kobi and Hachmo Yafit and Ramzia, {Abu Hamed} and Sasson Efrat and Fishlev Gregory and Lang Erez and Polak Nir and Doenyas Keren and Friedman Mony and Tal Sigal and Zemel Yonatan and Bechor Yair and Efrati Shai",

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year = "2020",

doi = "10.18632/aging.103571",

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AU - Amir, Hadanny

AU - Malka, Daniel Kotovsky

AU - Gil, Suzin

AU - Rahav, Boussi Gross

AU - Merav, Catalogna

AU - Kobi, Dagan

AU - Yafit, Hachmo

AU - Ramzia, Abu Hamed

AU - Efrat, Sasson

AU - Gregory, Fishlev

AU - Erez, Lang

AU - Nir, Polak

AU - Keren, Doenyas

AU - Mony, Friedman

AU - Sigal, Tal

AU - Yonatan, Zemel

AU - Yair, Bechor

AU - Shai, Efrati

PY - 2020

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N2 - More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.

AB - More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.

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Cognitive enhancement of healthy older adults using hyperbaric oxygen: A randomized controlled trial

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