Coexistence of thyroid autoimmunity with other autoimmune diseases: Friend or foe? Additional aspects on the mosaic of autoimmunity

Martine Szyper-Kravitz, Ibrahim Marai, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

Abstract

Autoimmunity encompasses a wide spectrum of diseases from organ-specific diseases like Hashimoto thyroiditis, to systemic diseases such as systemic lupus erythematosus. These diseases are characterized by inflammation and the production of a wide range of autoantibodies directed against multiple autoantigens. Although their etiology is still poorly understood, genetic, immunological, hormonal, and environmental factors are major predisposing and triggering factors. These multiple factors, like pieces in a mosaic, may interplay in different forms, leading to the expression of various autoimmune manifestations and diseases. This phenomenon, which has been referred by us as the "mosaic of autoimmunity", illuminates the diversity of autoimmune manifestations among susceptible individuals. From this theoretical framework we conducted a wide search of the literature, on the prevalence of thyroid autoimmunity, the commonest of the autoimmune conditions, among other autoimmune diseases, and discuss the possible clinical significance of this association.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalAutoimmunity
Volume38
Issue number3
DOIs
StatePublished - May 2005

Keywords

  • Anti-thyroglobulin
  • Anti-thyroid peroxidase
  • Mosaic of autoimmunity
  • Thyroid autoimmunity

Fingerprint

Dive into the research topics of 'Coexistence of thyroid autoimmunity with other autoimmune diseases: Friend or foe? Additional aspects on the mosaic of autoimmunity'. Together they form a unique fingerprint.

Cite this