TY - JOUR
T1 - Coexistence of the antiphospholipid syndrome and abdominal aortic aneurysm
AU - Szyper-Kravitz, Martine
AU - Altman, Arie
AU - de Carvalho, Jozélio Freire
AU - Bellisai, Francesca
AU - Galeazzi, Mauro
AU - Eshet, Yael
AU - Shoenfeld, Yehuda
PY - 2008/1
Y1 - 2008/1
N2 - The antiphospholipid syndrome is characterized by recurrent fetal loss, venous and/or arterial thrombosis, and thrombocytopenia associated with elevated titers of lupus anticoagulant and anticardiolipin antibodies. Although thrombosis is the characteristic vascular involvement in APS, the development of vascular aneurysms in patients with APS has been reported. We describe four patients with established APS who developed abdominal aortic aneurysm, and review the literature on previous published cases of arterial aneurysms developing in patients with APS. In addition, we discuss the possible pathophysiological association between APS and the development of this vascular abnormality.
AB - The antiphospholipid syndrome is characterized by recurrent fetal loss, venous and/or arterial thrombosis, and thrombocytopenia associated with elevated titers of lupus anticoagulant and anticardiolipin antibodies. Although thrombosis is the characteristic vascular involvement in APS, the development of vascular aneurysms in patients with APS has been reported. We describe four patients with established APS who developed abdominal aortic aneurysm, and review the literature on previous published cases of arterial aneurysms developing in patients with APS. In addition, we discuss the possible pathophysiological association between APS and the development of this vascular abnormality.
KW - Abdominal aortic aneurysm
KW - Antiphospholipid syndrome
KW - Arterial dissection
UR - http://www.scopus.com/inward/record.url?scp=41149091674&partnerID=8YFLogxK
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AN - SCOPUS:41149091674
SN - 1565-1088
VL - 10
SP - 48
EP - 51
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 1
ER -