Neuroleptic-induced parkinsonism and tardive dyskinesia are caused, respectively, by blockade and supersensitivity of dopaminergic receptors in striatum, and represent contrasting syndromes with regard to clinical presentation and management. Two patients are described in whom parkinsonism and tardive dyskinesia developed and coexisted, with marked severity, during chronic neuroleptic administration. Pharmacologic manipulations accelerating nigrostriatal transmission improved akinesia but intensified the dyskinesias, whereas suppression had opposite effects. It is hypothesized that the coexistence of these two opposing side effects is due to simultaneous blockade and supersensitivity of two different subclasses of striatal dopaminergic receptors.
|Number of pages||3|
|Journal||Journal of Clinical Psychiatry|
|State||Published - 1984|